Gwenn A Garden Selected Research

Ataxin-7

3/2013	Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7.
11/2011	Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration.
10/2006	Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport.
6/2002	Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.

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Gwenn A Garden Research Topics

Disease

6	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 12/2013
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 06/2002
5	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 03/2013 - 06/2002
4	Neoplasms (Cancer) 01/2022 - 07/2004
4	Neuroinflammatory Diseases 11/2020 - 12/2010
3	Disease Progression 07/2015 - 01/2008
2	Stroke (Strokes) 01/2020 - 01/2019
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2019 - 07/2015
2	Inflammation (Inflammations) 02/2016 - 01/2015
2	X-Linked Bulbo-Spinal Atrophy 09/2014 - 02/2009
2	Ataxia (Dyssynergia) 03/2013 - 10/2006
1	Neurotoxicity Syndromes (Toxic Encephalopathy) 01/2022
1	Multiple Sclerosis 01/2021
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Pathologic Processes 11/2020
1	AIDS-Related Complex (ARC) 01/2020
1	Hematologic Neoplasms (Hematological Malignancy) 01/2020
1	Central Nervous System Diseases (CNS Diseases) 10/2016
1	Autoimmune Diseases (Autoimmune Disease) 02/2016
1	Dementia (Dementias) 08/2015
1	Genomic Instability 01/2015
1	Cerebellar Diseases (Cerebellar Syndrome) 11/2011
1	Neurocognitive Disorders (Clerambault Syndrome) 10/2011
1	Motor Neuron Disease (Primary Lateral Sclerosis) 02/2009
1	Cone-Rod Dystrophies 01/2008
1	Carotid Artery Diseases 10/2007
1	Infections 08/2007
1	Ischemia 06/2006
1	Hemorrhage 03/2006
1	Carotid Stenosis (Carotid Artery Stenosis) 03/2006
1	Herpes Zoster 01/2004
1	Herpes Zoster Oticus (Geniculate Neuralgia) 01/2004
1	Facial Paralysis (Facial Palsy) 01/2004
1	Gait Ataxia 06/2002

Drug/Important Bio-Agent (IBA)

6	polyglutamineIBA 09/2014 - 06/2002
4	Amyloid (Amyloid Fibrils)IBA 01/2021 - 07/2015
4	Proteins (Proteins, Gene)FDA Link 04/2019 - 06/2002
4	Ataxin-7IBA 03/2013 - 06/2002
3	Presenilin-2IBA 01/2020 - 12/2013
3	Presenilin-1IBA 01/2020 - 07/2015
3	Transcription Factors (Transcription Factor)IBA 10/2011 - 07/2004
2	Chimeric Antigen ReceptorsIBA 01/2022 - 01/2020
2	MicroRNAs (MicroRNA)IBA 01/2021 - 02/2016
2	Protein Isoforms (Isoforms)IBA 01/2019 - 07/2015
2	Histones (Histone)IBA 01/2019 - 10/2013
2	Biomarkers (Surrogate Marker)IBA 10/2016 - 02/2016
2	Messenger RNA (mRNA)IBA 07/2015 - 08/2007
2	Androgen Receptors (Androgen Receptor)IBA 09/2014 - 02/2009
2	Peptide Hydrolases (Proteases)FDA Link 12/2013 - 08/2007
1	CytokinesIBA 01/2020
1	Caspase 3 (Caspase-3)IBA 01/2019
1	Amyloid beta-PeptidesIBA 01/2019
1	Apolipoprotein E4IBA 08/2015
1	SynucleinsIBA 08/2015
1	DNA-Binding Proteins (DNA Binding Protein)IBA 08/2015
1	Tumor Suppressor Protein p53IBA 01/2015
1	Tamoxifen FDA LinkGeneric 03/2013
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 04/2012
1	Glycoproteins (Glycoprotein)IBA 10/2011
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 12/2010
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2007
1	Nerve Growth Factors (Neurotrophins)IBA 06/2006
1	LipidsIBA 03/2006
1	Antiviral Agents (Antivirals)IBA 01/2004
1	Acyclovir (Aciclovir)FDA LinkGeneric 01/2004

Therapy/Procedure

4	Therapeutics 01/2020 - 01/2004
1	Immunotherapy 01/2022